CIPSM - Research Area F

Research Area F

2020

Tunable light and drug induced depletion of target proteins

2019

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

2018

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

A Visual-Cue-Dependent Memory Circuit for Place Navigation

Optogenetic Control of Neural Circuits in the Mongolian Gerbil

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

2017

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye

Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

Small Molecules for Early Endosome-Specific Patch Clamping

Partners in Crime

Photopharmacological control of bipolar cells restores visual function in blind mice

BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants

Linking Neurons to Network Function and Behavior by Two-Photon Holographic Optogenetics and Volumetric Imaging

Endoplasmic reticulum (ER) Ca²⁺-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

Gene therapy for achromatopsia

Quantitative LC–MS Provides No Evidence for m⁶dA or m⁴dC in the Genome of Mouse Embryonic Stem Cells and Tissues

Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions

miRNAs cooperate in apoptosis regulation during C. elegans development

In vivo deep two-photon imaging of neural circuits with the fluorescent Ca²⁺ indicator Cal-590

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

2016

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

Improved deep two-photon calcium imaging in vivo

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region

Super-resolution microscopy writ large

Programmed Cell Death During Caenorhabditis elegans Development

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

Photoswitchable diacylglycerols enable optical control of protein kinase C

Imaging of neuronal mitochondria in situ

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Impairments of neural circuit function in Alzheimer's disease

Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy

Ca_v1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors

A family of photoswitchable NMDA receptors

Entrapment of Water at the Transmembrane Helix–Helix Interface of Quiescin Sulfhydryl Oxidase 2

Deadly dowry: how engulfment pathways promote cell killing

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

2015

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology

Synthetic approaches towards alkaloids bearing α-tertiary amines

Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist

Rescue of long-range circuit dysfunction in Alzheimer's disease models

The loss of LRPPRC function induces the mitochondrial unfolded protein response

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ‑Secretase

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

An eight-step synthesis of epicolactone reveals its biosynthetic origin

Optical control of NMDA receptors with a diffusible photoswitch

Deep two-photon brain imaging with a red-shifted fluorometric Ca²⁺ indicator

Role of GxxxG Motifs in Transmembrane Domain Interactions

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotyp

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

Azobenzene-based inhibitors of human carbonic anhydrase II

Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues

TRPC3‐dependent synaptic transmission in central mammalian neurons

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice

cGMP/PKG Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of CNG Channel-Deficient Mice

Photoswitchable fatty acids enable optical control of TRPV1

αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell–related features

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

Biomimetic Total Synthesis of Santalin Y

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3^−/−/Nrl^−/− mice, an all-cone model of CNGA3 achromatopsia

Neuronal hyperactivity – A key defect in Alzheimer's disease?

Neuroscience’s answer to the Nobel Prize - The Brain Prize 2015 - goes in part to CIPSM researcher Arthur Konnerth for the invention, development and application of the revolutionary technique two-photon microscopy

AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Calculated Nuclear Magnetic Resonance Spectra of Polytwistane and Related Hydrocarbon Nanorods

Redox imaging using genetically encoded redox indicators in zebrafish and mice

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice

Dendritic function in vivo

2014

Synthetic Studies toward Polytwistane Hydrocarbon Nanorods

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo

DNA methylation and differential gene regulation in photoreceptor cell death

In Vivo Imaging of Mitochondria in Intact Zebrafish Larvae

Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation

Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition

An assay to image neuronal microtubule dynamics in mice

Total Synthesis of the Proposed Structure of Trichodermatide A

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice

Cellular Zinc Levels Are Modulated By Trpml1-Tmem163 Interaction.

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors

Pathological a-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen

CNS Axons Globally Increase Axonal Transport after Peripheral Conditioning

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

Rapid adaptive optical recovery of optimal resolution over large volumes

Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish

Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

NMDA Receptor-Dependent Multidendrite Ca2+ Spikes Required for Hippocampal Burst Firing In Vivo

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

Local domains of motor cortical activity revealed by fiber-optic calcium recordings in behaving nonhuman primates

2013

A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor

Sick Sinus Syndrome in HCN1-Deficient Mice

Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2

The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics

cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function

A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis

CATP-6, a C. elegans Ortholog of ATP13A2 PARK9, Positively Regulates GEM-1, an SLC16A Transporter

Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo

Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans

Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

Gene replacement therapy for retinal CNG channelopathies

Reactivation of the Same Synapses during Spontaneous Up States and Sensory Stimuli

Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins

Studies toward the Biomimetic Total Synthesis of (−)-PF-1018

Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR

Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo

Optical control of metabotropic glutamate receptors

Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins

Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes

Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)

Structural Properties of Model Phosphatidylcholine Flippases

Sequential Photo-bleaching to Delineate Single Schwann Cells at the Neuromuscular Junction

Recombinant Expression, Biophysical Characterization, and Cardiolipin-Induced Changes of Two Caenorhabditis elegans Cytochrome c Proteins