CIPSM - Research Area B

Research Area B

2021

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation

2020

2019

Chapter One - Functional principles and regulation of molecular chaperones

2018

The Antibody Light-Chain Linker Regulates Domain Orientation and Amyloidogenicity

Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor

A single residue switch reveals principles of antibody domain integrity

Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB

A switch point in the molecular chaperone Hsp90 responding to client interaction

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ

Structural components involved in plastid protein import

Plant Mitochondrial Inner Membrane Protein Insertion

On the Trails of the Proteasome Fold: Structural and Functional Analysis of the Ancestral β-Subunit Protein Anbu

Phosphorylation of the outer membrane mitochondrial protein OM64 influences protein import into mitochondria

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate

2017

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly

The Y. bercovieri Anbu crystal structure sheds light on the evolution of highly (pseudo)symmetric multimers

To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay

Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

3.2-Å-resolution structure of the 90S preribosome beforeA1 pre-rRNA cleavage

Proximity‐Triggered Covalent Stabilization of Low‐Affinity Protein Complexes In Vitro and In Vivo

A peptide extension dictates IgM assembly

Determinants of the assembly and function of antibody variable domains

The Plasticity of the Hsp90 Co-chaperone System

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α₄β₃ Complex

A chemical compound inhibiting the Aha1-Hsp90 chaperone complex

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo

Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization

The HSP90 chaperone machinery

ThT 101: a primer on the use of thioflavin T to investigate amyloid formation

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Structure of the 40S–ABCE1 post-splitting complex in ribosome recycling and translation initiation

TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana

Sucrose sensing through nascent peptide‐meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2

Assembly-induced folding regulates interleukin 12 biogenesis and secretion

New insights into the intracellular distribution pattern of cationic amphiphilic drugs

An alternative splice variant of human αA-crystallin modulates the oligomer ensemble and the chaperone activity of α-crystallins

Import of Soluble Proteins into Chloroplasts and Potential Regulatory Mechanisms

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains

Cotranslational folding of spectrin domains via partially structured states

2016

Chloroplast differentiation in the growing leaves of Arabidopsis thaliana

The PPR protein SLOW GROWTH 4 is involved in editing of nad4 and affects the splicing of nad2 intron 1

The CCAAT-binding complex (CBC) in Aspergillus species

Structural basis for ArfA–RF2-mediated translationtermination on mRNAs lacking stop codons

Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

Covalently circularized nanodiscs for studying membrane proteins and viral entry

Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i

Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response

Ycf1/Tic214 Is Not Essential for the Accumulation of Plastid Proteins

Importance of cycle timing for the function of the molecular chaperone Hsp90

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome

Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90

Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro

Plant mitochondria contain the protein translocase subunits TatB and TatC

Thylakoid Membrane Architecture in Synechocystis Depends on CurT, a Homolog of the Granal CURVATURE THYLAKOID1 Proteins

Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

In vivo aspects of protein folding and quality control

OEP40: a Regulated Glucose-Permeable, β-Barrel Solute Channel in the Chloroplast Outer Envelope Membrane

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Once upon a Time – Chloroplast Protein Import Research from Infancy to Future Challenges

Construction and evaluation of yeast expression networks by database-guided predictions

Rational Design of Proteasome Inhibitors as Antimalarial Drugs

The calmodulin-like proteins AtCML4 and AtCML5 are single-pass membrane proteins targeted to the endomembrane system by an N-terminal signal anchor sequence

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

The Arabidopsis Protein CGLD11 Is Required for Chloroplast ATP Synthase Accumulation

Failure of RQC machinery causes protein aggregation and proteotoxic stress

Translation regulation via nascent polypeptide-mediated ribosome stalling

Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments

A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

Structure and function of α-crystallins: Traversing from in vitro to in vivo

Vast majority of the proteasome core structures added to the wwPDB archive from CIPSM investigator Michael Groll’s group

2015

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp9

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

In vitro analyses of mitochondrial ATP/phosphate carriers from Arabidopsis thaliana revealed unexpected Ca2+-effects

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

Locking GTPases covalently in their functional states

Azobenzene-based inhibitors of human carbonic anhydrase II

daf-41/p23: A Small Protein Heating Up Lifespan Regulation

Covalent Protein Labeling by Enzymatic Phosphocholination

The extreme Albino3 (Alb3) C terminus is required for Alb3 stability and function in Arabidopsis thaliana

Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE)

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pHDependent Conformational Changes

Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

Role of the cytosolic loop C2 and the C-terminus of YidC in ribosome binding and insertion activity

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors

A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation

A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Phosphomimicking within the transit peptide of pHCF136 leads to reduced photosystem II accumulation in vivo

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling

Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

YCF1: A Green TIC?

Scalable Production in Human Cells and Biochemical Characterization of Full-Length Normal and Mutant Huntingtin

A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding

Identification of cleavage sites and substrate proteins for two mitochondrial intermediate peptidases in Arabidopsis thaliana

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

Oep23 forms an ion channel in the chloroplast outer envelope

Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914

FAX1, a Novel Membrane Protein Mediating Plastid Fatty Acid Export

Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes

Redox meets protein trafficking

Indolo-Phakellins as β5-Specific Noncovalent Proteasome Inhibitors

2014

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

Hop/Sti1 phosphorylation inhibits its co-chaperone function

Molecular Perspectives on Protein Adenylylation

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site

Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions

Interactions of the natural product kendomycin and the 20S proteasome

A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains

α-Keto Phenylamides as P1′-Extended Proteasome Inhibitors

The Formation of Pyrroline and Tetrahydropyridine Rings in Amino Acids Catalyzed by Pyrrolysine Synthase (PylD)

The Legionella longbeachae Icm/Dot Substrate SidC Selectively Binds Phosphatidylinositol 4-Phosphate with Nanomolar Affinity and Promotes Pathogen Vacuole-Endoplasmic Reticulum Interactions

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

Protein Folding by Interaction

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

Enzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome Inhibitor

Principles and engineering of antibody folding and assembly

Reaction Mechanism of Adenylyltransferase DrrA from Legionella pneumophila Elucidated by Time-Resolved Fourier Transform Infrared Spectroscopy

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Induced-Fit Mechanism in Class I Terpene Cyclases

Insights into the Binding of Pyridines to the Iron−Sulfur Enzyme IspH

GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease–Inhibitor Interactions

Versatile C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting

The structure of the N-terminal domain of the Legionella protein SidC

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

A new system for naming ribosomal proteins

Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the α-Ketoamide Electrophile as an Auspicious Reversible Lead Moti

Phosphorylation of Arabidopsis transketolase at Ser428 provides a potential paradigm for the metabolic control of chloroplast carbon metabolism

Direkte Modulation von Rab-GTPase-Effektor-Wechselwirkungen

Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism

Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD

Flavoenzyme-Catalyzed Formation of Disulfide Bonds in Natural Products

Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences

Exploring Adenylylation and Phosphocholination as Post-Translational Modifications

Applied techniques for mining natural proteasome inhibitors

2013

Exploring Adenylylation and Phosphocholination as Post-Translational Modifications

Quantification of Interaction Strengths between Chaperones and Tetratricopeptide Repeat Domain-containing Membrane Proteins

Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition

Regulated structural transitions unleash the chaperone activity of αB-crystallin

Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters

Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex

Mechanical Stability of the Antibody Domain CH3 Homodimer in Different Oxidation States

Identification of CP12 as a Novel Calcium-Binding Protein in Chloroplasts

Calmodulin-like protein AtCML3 mediates dimerization of peroxisomal processing protease AtDEG15 and contributes to normal peroxisome metabolism

Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy

Modulation of Small GTPases by Legionella

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

Structures of the human and Drosophila 80S ribosome

Dimerized Linear Mimics of a Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome

Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action

The chaperone Hsp90: changing partners for demanding clients

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

Conformational Selection in Substrate Recognition by Hsp70 Chaperones

RabGEFs are a major determinant for specific Rab membrane targeting

Structural and Functional Analysis of the DEAF-1 and BS69 MYND Domains

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB

2012

Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail

Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT

Alternative bacterial two-component small heat shock protein systems

Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution

Arabidopsis thaliana Oxa proteins locate to mitochondria and fulfill essential roles during embryo development

Characterization of Enzymes from Legionella pneumophila Involved in Reversible Adenylylation of Rab1 Protein

Nucleus-Encoded Light-Harvesting Chlorophyll a/b Proteins are Imported Normally into Chlorophyll b-free Chloroplasts of Arabidopsis

The first alpha-helical domain of the vesicle-inducing protein in plastids 1 promotes oligomerization and lipid binding

Essential Role of VIPP1 in Chloroplast Envelope Maintenance in Arabidopsis

AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

Depletion of leaf-type ferredoxin-NADP+ oxidoreductase results in the permanent induction of photoprotective mechanisms in Arabidopsis chloroplasts

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

Identification of a Hypochlorite-specific Transcription Factor from Escherichia coli

Programmed cell death in Ricinus and Arabidopsis: the function of KDEL cysteine peptidases in development

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins

Chloroplast-localized protein kinases: a step forward towards a complete inventory

The role of calcium in chloroplasts—an intriguing and unresolved puzzle

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

A toolset of aequorin expression vectors for in planta studies of subcellular calcium concentrations in Arabidopsis thaliana

2011

Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach

The phosphorylation state of chloroplast transit peptides regulates preprotein import

The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination

Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach

The Arabidopsis calmodulin-like proteins AtCML30 and AtCML3 are targeted to mitochondria and peroxisomes, respectively

How kinesin-2 forms a stalk

Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import

Firefly luciferase mutants as sensors of proteome stress

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53

The Cytosolic Kinases STY8, STY17, and STY46 Are Involved in Chloroplast Differentiation in Arabidopsis

Protein Import into Chloroplasts: Dealing with the (Membrane) Integration Problem

Cytosolic HSP90 Cochaperones HOP and FKBP Interact with Freshly Synthesized Chloroplast Preproteins of Arabidopsis

Technical note: Brassica rapa: a new model plant for the isolation of chloro-plasts and biochemical studies

Total Chemical Synthesis of an Integral Membrane Enzyme: Diacylglycerol Kinase from Escherichia coli

Closing In on the Hsp90 Chaperone-Client Relationship

Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction

Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptidebinding activity

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

Reduction of disulphide bonds unmasks potent antimicrobial activity of human Beta-defensin 1

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

2010

Approaching the Secrets of N-Glycosylation in Aspergillus fumigatus: Characterization of the AfOch1 Protein

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner

The Heat Shock Response: Life on the Verge of Death

Protein import into chloroplasts—How chaperones feature into the game

Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function

Dosage compensation and the global re-balancing of aneuploid genomes

Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle

Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ

A new concept for ferredoxin–NADP(H) oxidoreductase binding to plant thylakoids

Redox extends its regulatory reach to chloroplast protein import

Structural and Mechanical Hierarchies in the Alpha Crystallin Domain Dimer of the Hyperthermophilic Small Heat Shock Protein Hsp16.5

NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding

Dissecting the Alternatively Folded State of the Antibody Fab Fragment

The plant PRAT proteins – preprotein and amino acid transport in mitochondria and chloroplasts

Intramembrane Proteolysis of Mgm1 by the Mitochondrial Rhomboid Protease Is Highly Promiscuous Regarding the Sequence of the Cleaved Hydrophobic Segment

Independent evolution of the core domain and its flanking sequences in small heat shock proteins

Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus

AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus

Evolution of Escherichia coli for growth at high temperatures

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain

Regions Outside the Alpha-Crystallin Domain of the Small Heat Shock Protein Hsp26 Are Required for Its Dimerization

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

Redox-regulation of protein import into chloroplasts and mitochondria: Similarities and differences.

The many faces of the mitochondrial TIM23 complex

Protein import into chloroplasts: The Tic complex and its regulation

Coupled chaperone action in folding and assembly of hexadecameric Rubisco

A coronin7 homolog with functions in actin-driven processes

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

2009

How antibodies fold

ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1

Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium

Alb4 of Arabidopsis Promotes Assembly and Stabilization of a Non Chlorophyll-Binding Photosynthetic Complex, the CF1CF0–ATP Synthase

The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity

The charged linker region is an important regulator of Hsp90 function

The Folding Pathway of the Antibody VL Domain

Arabidopsis Tic62 and Ferredoxin-NADP(H) Oxidoreductase Form Light-Regulated Complexes That Are Integrated into the Chloroplast Redox Poise

Arabidopsis OBG-Like GTPase (AtOBGL) Is Localized in Chloroplasts and Has an Essential Function in Embryo Development

Calcium regulation in endosymbiotic organelles of plants

Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization

Hsp90 is regulated by a switch point in the C-terminal domain

NMR Structure of a Monomeric Intermediate on the Evolutionarily Optimized Assembly Pathway of a Small Trimerization Domain

Structural and functional diversity in the family of small heat shock proteins from the parasite Toxoplasma gondii

The eye lens chaperone alpha-crystallin forms defined globular assemblies

Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion

Preprotein Import into Chloroplasts via the Toc and Tic Complexes Is Regulated by Redox Signals in Pisum sativum

Arabidopsis ATPase family gene 1-like protein 1 is a calmodulin-binding AAA+-ATPase with a dual localization in chloroplasts and mitochondria

A search for factors influencing etioplast - chloroplast transition

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

Graduate School Life Science Munich (LSM)

Interaction of human heat shock protein 70 with tumor-associated peptides

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

Rapid Matrix-Assisted Refolding of Histidine-Tagged Proteins

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

Calcium depletion and calmodulin inhibition affect the import of nuclear-encoded proteins into plant mitochondria

Protein import machineries in endosymbiotic organelles

Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import

The Native 3D Organization of Bacterial Polysomes

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

Local conformational dynamics in alpha-helices measured by fast triplet transfer

2008

Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex

Characterization of TIC110, a channel-forming protein at the inner envelope membrane of chloroplasts, unveils a response to Ca2+ and a stromal regulatory disulfide bridge

Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion Protein

Import of preproteins into the chloroplast inner envelope membran

Rheology

Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling

The Actinome of Dictyostelium discoideum in Comparison to Actins and Actin-Related Proteins from Other Organisms

The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity

Effect of Thioxopeptide Bonds on r-Helix Structure and Stability

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

Contribution of Trimeric Autotransporter C-Terminal Domains of Oligomeric Coiled-Coil Adhesin (Oca) Family Members YadA, UspA1, EibA, and Hia to Translocation of the YadA Passenger Domain and Virulence of Yersinia enterocolitica

Actin: its cumbersome pilgrimage through cellular compartments

Energetics of protein translocation into mitochondria

Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding

Unusual, Virulence Plasmid-Dependent Growth Behavior of Yersinia enterocolitica in Three-Dimensional Collagen Gels

TIC62 Redox-regulated Translocon Composition and Dynamics

Structural Dynamics of Archaeal Small Heat Shock Proteins

Activation of the Chaperone Hsp26 is Controlled by the Rearrangement of Its Thermosensor Domain

2007

Properties of the Kinesin-1 motor DdKif3 from Dictyostelium discoideum

A step dissected

A Grp on the Hsp90 Mechanism

CP250, a Novel Acidic Coiled Coil Protein of the Dictyostelium centrosome, Affects Growth, Chemotaxis, and the Nuclear Envelope

The ATP-ase cycle of the endoplamic chaperone GRP94

Protein transport in chloroplasts - targeting to the intermembrane space