Chapter One - Functional principles and regulation of molecular chaperones
The Antibody Light-Chain Linker Regulates Domain Orientation and Amyloidogenicity
Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor
A single residue switch reveals principles of antibody domain integrity
Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
A switch point in the molecular chaperone Hsp90 responding to client interaction
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency
Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ
Structural components involved in plastid protein import
Plant Mitochondrial Inner Membrane Protein Insertion
On the Trails of the Proteasome Fold: Structural and Functional Analysis of the Ancestral β-Subunit Protein Anbu
Phosphorylation of the outer membrane mitochondrial protein OM64 influences protein import into mitochondria
The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate
Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly
The Y. bercovieri Anbu crystal structure sheds light on the evolution of highly (pseudo)symmetric multimers
To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P
3.2-Å-resolution structure of the 90S preribosome beforeA1 pre-rRNA cleavage
Proximity‐Triggered Covalent Stabilization of Low‐Affinity Protein Complexes In Vitro and In Vivo
A peptide extension dictates IgM assembly
Determinants of the assembly and function of antibody variable domains
The Plasticity of the Hsp90 Co-chaperone System
The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex
Ubiquitination of stalled ribosome triggers ribosome-associated quality control
MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors
An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome
Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands
Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling
Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo
Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ
Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization
The HSP90 chaperone machinery
ThT 101: a primer on the use of thioflavin T to investigate amyloid formation
The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells
Structure of the 40S–ABCE1 post-splitting complex in ribosome recycling and translation initiation
TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana
Sucrose sensing through nascent peptide‐meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2
Assembly-induced folding regulates interleukin 12 biogenesis and secretion
New insights into the intracellular distribution pattern of cationic amphiphilic drugs
An alternative splice variant of human αA-crystallin modulates the oligomer ensemble and the chaperone activity of α-crystallins
Import of Soluble Proteins into Chloroplasts and Potential Regulatory Mechanisms
Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
Cotranslational folding of spectrin domains via partially structured states
Chloroplast differentiation in the growing leaves of Arabidopsis thaliana
The PPR protein SLOW GROWTH 4 is involved in editing of nad4 and affects the splicing of nad2 intron 1
The CCAAT-binding complex (CBC) in Aspergillus species
Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons
Structural basis for ArfA–RF2-mediated translationtermination on mRNAs lacking stop codons
The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins
Covalently circularized nanodiscs for studying membrane proteins and viral entry
Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i
Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response
Ycf1/Tic214 Is Not Essential for the Accumulation of Plastid Proteins
Importance of cycle timing for the function of the molecular chaperone Hsp90
Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential
Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90
Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro
Plant mitochondria contain the protein translocase subunits TatB and TatC
Thylakoid Membrane Architecture in Synechocystis Depends on CurT, a Homolog of the Granal CURVATURE THYLAKOID1 Proteins
Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control
Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP
A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
In vivo aspects of protein folding and quality control
OEP40: a Regulated Glucose-Permeable, β-Barrel Solute Channel in the Chloroplast Outer Envelope Membrane
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
Once upon a Time – Chloroplast Protein Import Research from Infancy to Future Challenges
Construction and evaluation of yeast expression networks by database-guided predictions
Rational Design of Proteasome Inhibitors as Antimalarial Drugs
The calmodulin-like proteins AtCML4 and AtCML5 are single-pass membrane proteins targeted to the endomembrane system by an N-terminal signal anchor sequence
The Arabidopsis Protein CGLD11 Is Required for Chloroplast ATP Synthase Accumulation
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
Failure of RQC machinery causes protein aggregation and proteotoxic stress
Translation regulation via nascent polypeptide-mediated ribosome stalling
Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments
A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions
Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA
Structure and function of α-crystallins: Traversing from in vitro to in vivo
Vast majority of the proteasome core structures added to the wwPDB archive from CIPSM investigator Michael Groll’s group
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp9
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association
Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine
Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis
The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation
Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites
Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation
The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client
In vitro analyses of mitochondrial ATP/phosphate carriers from Arabidopsis thaliana revealed unexpected Ca2+-effects
Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions
Azobenzene-based inhibitors of human carbonic anhydrase II
daf-41/p23: A Small Protein Heating Up Lifespan Regulation
The extreme Albino3 (Alb3) C terminus is required for Alb3 stability and function in Arabidopsis thaliana
Role of the cytosolic loop C2 and the C-terminus of YidC in ribosome binding and insertion activity
A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Phosphomimicking within the transit peptide of pHCF136 leads to reduced photosystem II accumulation in vivo
Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules
YCF1: A Green TIC?
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation
Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure
Reaction Mechanism of Adenylyltransferase DrrA from Legionella pneumophila Elucidated by Time-Resolved Fourier Transform Infrared Spectroscopy
GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding
Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins
Chloroplast-localized protein kinases: a step forward towards a complete inventory
Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
Dosage compensation and the global re-balancing of aneuploid genomes
Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding
Evolution of Escherichia coli for growth at high temperatures
Alb4 of Arabidopsis Promotes Assembly and Stabilization of a Non Chlorophyll-Binding Photosynthetic Complex, the CF1CF0–ATP Synthase
Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
Import of preproteins into the chloroplast inner envelope membran
Rheology
Effect of Thioxopeptide Bonds on r-Helix Structure and Stability
TIC62 Redox-regulated Translocon Composition and Dynamics
The ATP-ase cycle of the endoplamic chaperone GRP94
Protein transport in chloroplasts - targeting to the intermembrane space
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