Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3

Angewandte Chemie, 2013, DOI: 10.1002/anie.201306376, Volume 52, Issue 44, pages 11656–11659 published on 20.09.2013
Angewandte Chemie, online article
For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.  

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