Multisubunit RNA Polymerases Melt Only a Single DNA Base Pair Downstream of the Active Site

J. Biol. Chem., 2007, 282, 21578-82 published on 27.07.2007
Journal of Biological Chemistry, online article
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription- coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.

Campus Movie 2020


Campus Movie 2012

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry