DNA photodamage recognition by RNA polymerase II

FEBS Lett, 2007, 581, 2757-60 published on 19.06.2007
FEBS Letters, online article
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription- coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.

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