Norbornenes in Inverse Electron-Demand Diels–Alder Reactions
Chemistry, 2013, DOI: 10.1002/chem.201301838, Volume 19, Issue 40, pages 13309–13312 published on 27.09.2013
Significant differences in the reactivity of norbornene derivatives in the inverse electron-demand Diels–Alder reaction with tetrazines were revealed by kinetic studies. Substantial rate enhancement for the exo norbornene isomers was observed (see scheme). Quantum-chemical calculations were used to rationalize and support the observed experimental data.